24-Week Trial of Hydrogen-Rich Water in Adults with Metabolic Syndrome
In this study, the authors reported statistically significant changes in cholesterol, triglycerides, fasting glucose and HbA1c, as well as shifts in oxidative and inflammation-related markers.
Study Summary
This randomized, placebo-controlled trial examined adults with metabolic syndrome over a 24-week period. Participants consumed hydrogen-rich water or placebo daily. Researchers measured changes in blood lipids, glucose-related markers, oxidative indicators and inflammation-related markers.
Results
The authors reported the following numerical changes in the hydrogen-rich water group over the 24-week period:
- Total cholesterol: decreased by 18.5 mg/dL
≈ 9.9% reduction - Triglycerides: decreased by 47 mg/dL
≈ 24.9% reduction - Fasting blood glucose: decreased from 121.5 mg/dL to 103.1 mg/dL
≈ 15.1% reduction - Hemoglobin A1c (HbA1c): decreased by ~12% (as reported by the authors)
In this study, the authors reported that these changes were statistically significant (P < 0.05).
Oxidation-related markers (MDA and d-conjugate) also decreased, while vitamins E and C increased. TNF-α, IL-6 and CRP were also reported to be reduced in the hydrogen group (P < 0.05). All outcomes except TBARS (P = 0.309) differed from placebo in this trial.
Why They Measured These Markers
Researchers monitor these markers because they help identify trends in blood lipids, glucose regulation, oxidative processes and inflammation pathways. These indicators can shift due to many factors, including diet, physical activity, stress and intervention strategies. In this trial, the reported values reflect the specific study design, population and measurement methods.
Important Note
These results describe outcomes from this single research study. They are not general health claims and do not describe the effects of any product.
Human Trial of Hydrogen-Rich Water in Resistance Training
In this study, the authors reported statistically significant differences in blood lactate values and muscle soreness between the hydrogen-rich water condition and placebo, along with changes in exercise-related performance markers.
Study Summary
This randomized, double-blind, placebo-controlled cross-over trial included 12 men (mean ± SD age 23.8 ± 1.9 years).
Participants consumed 1,260 mL of hydrogen-rich water or placebo before resistance training.
Researchers measured set completion time, blood lactate, ratings of perceived exertion, creatine kinase, muscle soreness (VAS), countermovement jump and heart rate variability at baseline and at 30 minutes, 6 hours and 24 hours of recovery.
Results
Mid-way through the session:
- Hydrogen-rich water group: 5.3 mmol/L
- Placebo group: 6.5 mmol/L
Difference: −1.2 mmol/L (p ≤ 0.008)
This number shows the hydrogen group had lower lactate values at that point in the test.
Immediately after the session:
- Hydrogen-rich water group: 5.1 mmol/L
- Placebo group: 6.3 mmol/L
Difference: −1.2 mmol/L (p ≤ 0.008)
This shows a similar difference right after the exercise was completed.
Muscle soreness (24 hours later):
- Hydrogen-rich water group: 26 mm
- Placebo group: 41 mm
Difference: −15 mm (p = 0.002)
These values reflect the soreness scores the participants recorded on a visual scale.
Set completion time (lunges):
The hydrogen-rich water group completed the lunge set in less time than placebo. (p < 0.001) Numerical values were not provided in the published summary.
The authors reported that all of these differences were statistically significant within the conditions tested.
Why They Measured These Markers
Researchers track markers such as blood lactate, perceived soreness and set completion time to observe trends related to fatigue, effort and recovery in exercise studies. These values can shift due to training load, hydration, supplementation, recovery strategies and individual differences. In this trial, the reported values reflect the specific protocol, population and measurement methods.
Important Note
These results describe outcomes from this single research study. They are not general health claims and do not describe the effects of any product.
Acute Trial of Hydrogen-Rich Water in Middle-Distance Runners
In this study, the authors reported statistically significant differences in several exercise-related markers between the hydrogen-rich water condition and placebo during aerobic and anaerobic testing.
Study Summary
This randomized, double-blind, placebo-controlled crossover trial included 22 male middle-distance runners. Participants consumed hydrogen-rich water or placebo before completing aerobic and anaerobic exercise tests. Researchers measured maximum aerobic speed (MAS), time to exhaustion, blood lactate, heart-rate responses and ratings of perceived exertion during exercise.
Results
Maximum Aerobic Speed (MAS):
- Hydrogen-rich water condition: 16.9 ± 0.4 km/h
- Placebo condition: 16.5 ± 0.5 km/h
Difference: +0.4 km/h (p < 0.01)
These values reflect the running speeds recorded at the termination point of the aerobic test.
Time to Exhaustion:
- Hydrogen-rich water condition: 13.3 ± 2.0 minutes
- Placebo condition: 12.2 ± 1.8 minutes
Difference: +1.1 minutes (p < 0.01)
This shows the recorded time participants maintained the final exercise stage before stopping.
Anaerobic Power Output (W/kg):
- Hydrogen-rich water condition: 7.35 ± 0.47
- Placebo condition: 7.04 ± 0.39
Difference: +0.31 W/kg (p < 0.05)
These were the measured power outputs during the anaerobic portion of the test.
Blood Lactate at 3 minutes post-exercise:
- Hydrogen-rich water condition: 11.4 ± 0.5 mmol/L
- Placebo condition: 12.2 ± 0.6 mmol/L
Difference: −0.8 mmol/L (p < 0.05)
This reflects lactate levels measured shortly after anaerobic exertion.
Perceived Exertion (RPE):
Hydrogen-rich water condition: lower RPE scores reported (p < 0.05). Numerical values were not provided in the summary, but the authors reported the direction and statistical significance.
The authors reported that these differences were statistically significant within the conditions tested.
Why They Measured These Markers
Researchers use markers such as maximum aerobic speed, time to exhaustion, blood lactate and subjective exertion scores to observe physical performance responses during aerobic and anaerobic exercise. These metrics can shift due to effort level, hydration, pacing, supplementation and test design. In this study, the reported values show how these indicators changed between the two conditions under the specific experimental protocol.
Important Note
These results describe outcomes from this single research study. They are not general health claims and do not describe the effects of any product.
Additional Studies
6-Month Trial of Hydrogen-Rich Water in Adults Aged 70 Years and Over
In this study, the authors reported numerical changes in molecular and phenotypic biomarkers that researchers associate with biological aging processes after daily intake of hydrogen-rich water compared with a control drink over a 6-month period.
Study Summary
This randomized, controlled pilot trial included 40 adults aged 70 years and older. Participants consumed either 0.5 L per day of hydrogen-rich water (15 ppm hydrogen) or a control drink containing 0 ppm hydrogen for six months.
Researchers measured changes in telomere length, molecular markers, brain metabolites, and physical-performance metrics.
Randomised Trial of Hydrogen-Rich Water Bathing for Acute Ankle Sprain in Professional Athletes
In this study, the authors reported that hydrotherapy with hydrogen-rich water was equivalent to a standard RICE protocol in professional athletes with acute ankle sprain in measures of swelling, range of motion and balance.
Study Summary
This randomized, parallel-group non-inferiority pilot trial included 18 male professional athletes (mean ± SD age 23.7 ± 4.0 years; weight 78.6 ± 5.7 kg; height 182.5 ± 4.3 cm) who suffered an acute sport-related ankle sprain. Participants were assigned to either a hydrogen-rich water ankle bathing group (n = 9) or a standard RICE (rest-ice-compression-elevation) protocol group (n = 9). The hydrogen group received six 30-minute ankle baths with hydrogen-rich water throughout the first 24 hours post-injury (one every ~4 hours). The RICE group received ice packs for 20 minutes every 3 hours, ankle compression and elevation for 24 hours. Researchers measured ankle swelling, range of motion, single-leg balance (eyes open/closed), and inflammatory biomarkers.
Hydrogen-Rich Water Bathing in Adults with Skin Conditions
In this study, the authors reported numerical changes in scoring systems after hydrogen-rich water bathing, compared with baseline values, in participants with psoriasis or atopic dermatitis.
Study Summary
This open-label, non-randomized trial included two participant groups:
- 41 adults with psoriasis vulgaris
- 48 adults with atopic dermatitis
Participants bathed in hydrogen-rich water for 10–20 minutes per session, twice weekly for 8 weeks. Researchers recorded changes in validated dermatology scoring systems at baseline and at the end of the study.
Single-Session Trial of Hydrogen-Rich Water Bathing After High-Intensity Exercise
In this study, the authors reported numerical differences in blood markers and soreness perception after a single 30-minute whole-body bath in supersaturated hydrogen-rich water compared with a control bath. Measurements were taken before and 24 hours after exercise.
Study Summary
This double-blind, crossover pilot trial involved six healthy young men (average age 24 years) who completed a high-intensity leg-press exercise designed to induce muscle soreness.
After each exercise session, participants were immersed up to the neck in either a hydrogen-rich water bath (8 mg H₂ per L) or a control bath containing no hydrogen.
Researchers measured blood markers of muscle stress and inflammation, and recorded self-reported muscle soreness immediately after bathing and again 24 hours later.





