6-Month Trial of Hydrogen-Rich Water in Adults Aged 70 Years and Over

In this study, the authors reported numerical changes in molecular and phenotypic biomarkers that researchers associate with biological aging processes after daily intake of hydrogen-rich water compared with a control drink over a 6-month period.

Study Summary

This randomised, controlled pilot trial included 40 adults aged 70 years and older. Participants consumed either 0.5 L per day of hydrogen-rich water (15 ppm hydrogen) or a control drink containing 0 ppm hydrogen for six months. Researchers measured changes in telomere length, molecular markers, brain metabolites, and physical-performance metrics.

Results

Telomere Length (peripheral blood cells):

Hydrogen group: 0.99 → 1.02 (≈ +3.0%)

Control group: 0.92 → 0.79 (≈ −14.1%)

Reported treatment × time interaction: p = 0.049

TET2 Expression (mRNA):

Hydrogen group: 0.81 → 1.62 (≈ +100%)

Control group: 1.13 → 1.76 (≈ +55.8%)

Reported treatment × time interaction: p = 0.040

Brain-Related Biomarkers (Magnetic Resonance Spectroscopy):

The authors reported increases in choline and N-acetylaspartate (NAA) levels in specific brain regions in the hydrogen group compared with the control condition (p < 0.05).
(Numerical values were not disclosed in the published data.)

Physical Function (Chair-Stand Test):

The authors reported a significant difference in chair-stand test performance in the hydrogen group compared with the control group (P = 0.01). (Numerical values were not provided in the published paper.)

The authors reported that these numerical differences were statistically significant within the outcomes measured in this study.

Why They Measured These Markers

Researchers measure telomere length, molecular-signalling markers, brain-related metabolites, and physical-performance indicators to monitor trends linked to biological-aging research. These values can shift due to dietary habits, lifestyle factors, intervention methods, and statistical variability. In this trial, the reported changes reflect measurements collected through the specific tools used by the investigators.

Important Note: These results describe outcomes from this single research study. They are not general health claims and do not describe the effects of any product.

Read the full study here.